Grass carp TGF-β1 impairs IL-1β signaling in the inflammatory responses: Evidence for the potential of TGF-β1 to antagonize inflammation in fish
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- 作者：Xinyan Wang ; Xiao Yang ; Chao Wen ; Yajun Gao ; Lei Qin ; Shengnan Zhang ; Anying Zhang ; Kun Yang ; Hong Zhou ; zhouhongzh@uestc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-1β ; TGF-β1 ; Antagonistic effect ; Inflammatory response ; Grass carp
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：121-127
- 全文大小：1046 K
文摘
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LPS significantly induced grass carp TGF-β1 and IL-1β mRNA expression.
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Stimulation of IL-1β mRNA expression by LPS was IL-1β-independent.
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TGF-β1 impaired basal and LPS-induced IL-1β mRNA expression.
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TGF-β1 modulated IL-1β signaling via affecting its signaling molecules' expression.
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TGF-β1 impeded bacteria-induced IL-1β expression in grass carp head kidney.
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