Optogenetic Stimulation of Frontal D1 Neurons Compensates for Impaired Temporal Control of Action in Dopamine-Depleted Mice

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• 作者：Young-Cho Kim¹ ; Sang-Woo Han¹ ; Stephanie L. Alberico¹ ; Rafael N. Ruggiero¹ ; ² ; Benjamin De Corte¹ ; Kuan-Hua Chen⁴ ; Nandakumar S. Narayanan¹ ; ³ ; ⁵ ; ^{nandakumar-narayanan@uiowa.edu}
• 关键词：prefrontal cortex ; interval timing ; dopamine receptors ; mesocortical projections ; optogenetics
• 刊名：Current Biology
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：39-47
• 全文大小：2441 K
• 卷排序：27

文摘

Humans and mice have dopamine-dependent delta rhythms in medial frontal cortex Stimulating medial frontal neurons expressing D1DRs improves temporal processing Delta stimulation of medial frontal neurons at 2 Hz can improve interval timing