Genomic and proteomic analysis of the inhibition of synthesis and secretion of aldosterone hormone induced by quinocetone in NCI-H295R cells
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- 作者：Xu Wanga ; Yijie Baib ; Guyue Chengb ; Awais Ihsand ; Feng Zhub ; Yulian Wangb ; Yanfei Taoc ; Dongmei Chenc ; Menghong Daic ; Zhengli Liuc ; Zonghui Yuana ; b ; c ; yuan5802@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Toxicology
- 出版年：2016
- 出版时间：28 March 2016
- 年：2016
- 卷：350-352
- 期：Complete
- 页码：1-14
- 全文大小：3275 K
文摘
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QCT showed the highest adrenal toxic effect among QdNOs in H295R cells.
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PKC, ERK, JNK, p38MAPK and Nrf2 pathways were involved in adrenal toxicity of QCT.
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CYP17A1, NR4A2 and G6PD were molecular targets in adrenal toxicity of QCT.
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CYP17A1 was the key switch to reduce the aldosterone production induced by QCT.
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Genomic and proteomic analysis provided new insight into adrenal toxicity of QdNOs.