Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting TGF-β receptor type I
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- 作者：Hongwei Lia ; 1 ; dr.hongweili@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Liu Yangb ; 1 ; drliuyang82@126.com" class="auth_mail" title="E-mail the corresponding author ; Yuebing Zhangc ; pedsurgao@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Zhigang Gaoc ; ebwk@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hypertrophic scar ; Fibroblasts ; Kaempferol ; TGF-β1/Smads ; TGFβRI
- 刊名：Biomedicine & Pharmacotherapy
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：967-974
- 全文大小：3177 K
文摘
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Kaempferol attenuates HPS formation in a mechanical load-induced mouse model.
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Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation.
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Kaempferol inhibits TGF-β/Smads signalling via selective binding to TGFβRI.