Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat
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- 作者：Haijing Denga ; Hong Xub ; Xianghong Zhangc ; Yue Sunb ; Ruimin Wangb ; Darrell Brannd ; Fang Yangb ; fangyang1978@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：N-acetyl-seryl-aspartyl-lysyl-proline ; Epithelial&ndash ; mesenchymal transition ; Type II alveolar epithelial cells ; TGF-β1/ROCK1 pathway ; Silicosis
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：294
- 期：Complete
- 页码：1-10
- 全文大小：3873 K
文摘
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EMT is a critical stage during the development of silicosis fibrosis.
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Ac-SDKP inhibits the EMT process in silicosis both in vivo and in vitro.
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Ac-SDKP inhibits the EMT process in silicosis via TGF-β1/ROCK1 pathway.