The poor recovery of neuromyelitis optica spectrum disorder is associated with a lower level of CXCL12 in the human brain
详细信息 查看全文
- 作者：Hao Kanga ; 1 ; Shanshan Caoa ; 1 ; Tingjun Chena ; 1 ; Zhaocai Jianga ; c ; Zihao Liua ; d ; Zhaohui Lia ; Yangang Weie ; Nanping Aie ; Quangang Xua ; Qing Linb ; qilin@uta.edu" class="auth_mail" title="E-mail the corresponding author ; Shihui Weia ; weishihui706@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuromyelitis optica spectrum disorders (NMOSDs) ; Glial fibrillary acidic protein (GFAP) ; Aquaporin 4 (AQP4) ; CXC-motif ligand 12 (CXCL12) ; Tumor necrosis factor α (TNFα)
- 刊名：Journal of Neuroimmunology
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：289
- 期：Complete
- 页码：56-61
- 全文大小：666 K
文摘
- •
CXCL12 in human brain was down-regulated in NMOSD patients with poor recovery.
- •
CXCL12 was negatively related with the up-regulation of NMO-IgG in patients' serum.
- •
CXCL12 was negatively related with the up-regulation GFAP in NMOSD patients' CSF.
- •
CXCL12 was related with TNFα concentration in NMOSD patients' CSF.
- •
Our work confirmed Patel's hypothesis (Acta neuropathologica. 2012; 124:847-60).