Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng

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• 作者：Qinge Ma ^{maqinge2010@163.com} ; Jin Tian ; Jianbo Yang ; Aiguo Wang ; Tengfei Ji ; Yangai Wang ; Yalun Su ; ^{suyalun@imm.ac.cn}
• 关键词：Murraya koenigii ; Carbazole alkaloid ; Hepatoprotective activity ; PTP1B inhibitory activity
• 刊名：Fitoterapia
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：87
• 期：Complete
• 页码：1-6
• 全文大小：347 K

文摘

Four new carbazole alkaloids (1-4) and fourteen known carbazole alkaloids (5-18) were isolated from Murraya koenigii. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 4, 6, 16, and 17 (10 ¦ÌM) had moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage. Compounds 11, 12 and 18 showed significant PTP1B inhibitory activity with IC₅₀ values of 1.773, 1.875 and 2.286 ¦ÌM, respectively.