DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection
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- 作者：Yangchao Dong1 ; Wei Ye1 ; Jing Yang1 ; Peijun Han ; Yuan Wang ; Chuantao Ye ; Daihui Weng ; Fanglin Zhang ; Zhikai Xu ; zhikaixu523@163.com" class="auth_mail" title="E-mail the corresponding author ; Yingfeng Lei ; yflei@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：DDX21 ; DENV ; NS2B/3 protease ; iTRAQ ; Innate immune response
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：648-653
- 全文大小：599 K
文摘
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DDX21 translocates from nucleus to cytoplasm in response to DENV infection.
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DDX21 is involved in activation of the innate immune response for the inhibition of DENV infection.
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The DENV NS2B/3 complex degraded DDX21 in cytoplasm to facilitate DENV replication.