Enzyme-based signal amplification of surface-enhanced Raman scattering in cancer-biomarker detection

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• 作者：Sujuan Ye^a ; Yaning Mao^a ; Yuanyuan Guo^a ; Shusheng Zhang^a ; ^b ; ^{shushzhang@126.com" class="auth_mail}
• 关键词：Biomarker ; Cancer ; Diagnostics ; DNA ; Enzyme ; Protein ; Signal amplification ; Single-nucleotide polymorphism ; Surface-enhanced Raman scattering (SERS) ; Therapeutics
• 刊名：TrAC Trends in Analytical Chemistry
• 出版年：March, 2014
• 年：2014
• 卷：55
• 期：Complete
• 页码：43-54
• 全文大小：3934 K

文摘

Technologies that use surface-enhanced Raman scattering (SERS) have experienced significant growth in biomedical research during the past four years. SERS signal amplification based on enzyme action recently attracted considerable attention due to the need for ultrasensitive bioassays and the trend towards miniaturized assays. This review highlights recent developments in SERS signal-amplification techniques based on enzyme action for cancer-biomarker detection, including multiplexed detection and identification of DNA, single-nucleotide polymorphisms, small bioactive molecules, protein, and tumor cells.