Surface modification via strain-promoted click reaction facilitates targeted lentiviral transduction
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- 作者：Yanjie Chua ; Yoon Hyeun Ouma ; 1 ; Isaac S. Carricoa ; b ; isaac.carrico@stonybrook.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lentivirus ; Gene therapy ; Metabolic labeling ; Unnatural glycans ; Sialic acid ; Bioorthogonal chemistry ; Targeting ; Cancer ; Tumor angiogenesis ; Surface engineering
- 刊名：Virology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：487
- 期：Complete
- 页码：95-103
- 全文大小：1390 K
文摘
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N-azidoacetyl sialic acid (SiaNAz) was metabolically introduced onto viral surface.
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Modification via strain-promoted click reaction yielded targeted viruses.
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This novel two-step labeling method exhibited remarkable flexibility.
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