TRB3 interacts with CtIP and is overexpressed in certain cancers

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• 作者：Jianmin Xu ; Shun Lv ; Yan Qin ; Fang Shu ; Yanjuan Xu ; Jian Chen ; Bing-e Xu ; Xiaoqing Sun ; Jun Wu
• 关键词：TRB3 ; CtIP ; Tumorigenesis ; Co-localization
• 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：1770
• 期：2
• 页码：273-278
• 全文大小：764 K

文摘

TRB3, a human homolog of Drosophila Tribbles, has been recently shown as a critical negative regulator of Akt and S6 kinase activation in a number of cellular processes. Here we found that TRB3 interacted with an important cell cycle regulator CtIP (CtBP-interacting protein) and the interaction involved the C-terminus of both proteins. Interestingly, TRB3 and CtIP co-localized to the nucleus in HeLa cells and exhibited a unique dot-like pattern. Finally, we demonstrated that TRB3 was overexpressed in multiple tumor tissues. Since CtIP plays important roles in cell cycle checkpoint control and it has been implicated in tumorigenesis, our data suggest that TRB3 may be involved in these biological processes through interacting with CtIP.