Efficacy of Pharmacokinetics-Directed Busulfan, Cyclophosphamide, and Etoposide Conditioning and Autologous Stem Cell Transplantation for Lymphoma: Comparison of a Multicenter Phase II Study and CIBMTR Outcomes
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- 作者：Christopher R. Flowers1 ; Luciano J. Costa2 ; Marcelo C. Pasquini3 ; Jennifer Le-Rademacher3 ; Michael Lill4 ; Tsiporah B. Shore5 ; William Vaughan6 ; Michael Craig7 ; Cesar O. Freytes8 ; Thomas C. Shea9 ; Mitchell E. Horwitz10 ; Joseph W. Fay11 ; Shin Mineishi12 ; Damiano Rondelli13 ; James Mason14 ; Ira Braunschweig15 ; Weiyun Ai16 ; Rosa F. Yeh17 ; Tulio E. Rodriguez18 ; Ian Flinn19 ; Terrance Comeau20 ; Andrew M. Yeager21 ; Michael A. Pulsipher22 ; Isabelle Bence-Bruckler23 ; Pierre Laneuville24 ; Philip Bierman25 ; Andy I. Chen26 ; Kazunobu Kato27 ; Yanlin Wang27 ; Cong Xu27 ; Angela J. Smith27 ; Edmund K. Waller1 ; ewaller@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Non-Hodgkin lymphoma ; Hodgkin lymphoma ; Busulfan ; Autologous stem cell transplantation ; Stem cell transplantation ; Lymphoma ; Chemotherapy
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：22
- 期：7
- 页码：1197-1205
- 全文大小：1155 K
文摘
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This phase II study of B cell NHL and HL examined the safety and efficacy of BuCyE.
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Individually adjusted busulfan was based on preconditioning PK.
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BuCyE outcomes were compared with contemporaneous recipients of BEAM registry data.
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BuCyE provided adequate disease control and safety in B cell NHL patients ≤ 65 years.
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BuCyE produced worse PFS in HL patients when compared with BEAM.