Molecular dynamics simulation of mechanical behavior of osteopontin-hydroxyapatite interfaces
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- 作者：Zheng Bo Lai ; Mingchao Wang ; Cheng Yan ; c2.yan@qut.edu.au" class="auth_mail ; Adekunle Oloyede
- 关键词：Osteopontin ; Hydroxyapatite ; Mechanical property ; Interface ; Molecular dynamics
- 刊名：Journal of the Mechanical Behavior of Biomedical Materials
- 出版年：August 2014
- 年：2014
- 卷：36
- 期：Complete
- 页码：12-20
- 全文大小：4425 K
文摘
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Interfacial mechanical behavior of OPN–HA was studied using molecular dynamics.
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Mechanical behavior relies on electrostatic attraction of acidic AA–calcium in HA.
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Higher energy is dissipated for OPN peptide with a higher no. of acidic AA.
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OPN peptide pulled in the interface direction results in higher energy dissipation.
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A new mechanism of energy dissipation in bone is suggested.