In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects tooth development in rhesus monkeys

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• 作者：Yasuda ; Iku ; Yasuda ; Mineo ; Sumida ; Hiroshi ; Tsusaki ; Hideshi ; Arima ; Akihiro ; Ihara ; Toshio ; et. al.
• 关键词：Dioxin ; TCDD ; Tooth ; Rhesus monkey ; Primate ; TDI ; Developmental toxicity ; LOAEL
• 刊名：Reproductive Toxicology
• 出版年：2005
• 出版时间：May - June, 2005
• 年：2005
• 卷：20
• 期：1
• 页码：21-30
• 全文大小：341 K

文摘

We thought to validate the current tolerable daily intake (TDI) value for dioxin (4 pg/kg) in Japan. Pregnant rhesus monkeys received an initial dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 0, 30, or 300 ng/kg subcutaneously) on day 20 of gestation; the dams received additional injection of 5 % of the initial dose every 30 days until day 90 after delivery. The teeth of stillborn, postnatally dead, and surviving offspring (now approximately 4 years old) were evaluated. None of the offspring in the 0 and 30 ng/kg groups (n = 17 and 15, respectively) had tooth abnormalities, whereas 10 of 17 in the 300 ng/kg had them. These findings suggest the lowest-observed adverse-effect level (LOAEL) for TCDD in the rhesus monkey is between 30 and 300 ng/kg, and probably is close to that for rodents (86 ng/kg) on which the current TDI was based. It is reasonable to conclude that the current TDI needs no immediate modification.