Investigating cerebral oedema using poroelasticity
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- 作者：John C. Vardakisa ; Dean Choub ; Brett J. Tullyc ; Chang C. Hungd ; e ; Tsong H. Leed ; Po-Hsiang Tsuif ; g ; Yiannis Ventikosa ; y.ventikos@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cerebral oedema ; Multiple-Network Poroelastic Theory ; Hydrocephalus ; Computational Fluid Dynamics ; Finite Element Method ; Intracranial Pressure ; Aquaporins ; Endoscopic ventriculostomy ; Fourth Ventricular Outlet Obstruction ; Periventricular lucency ; Gliosis
- 刊名：Medical Engineering & Physics
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：38
- 期：1
- 页码：48-57
- 全文大小：2226 K
文摘
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Multiple-Network Poroelastic Theory is used to develop a model of fluid regulation and tissue displacement.
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The model is used to investigate interstitial cerebral oedema formation and its alleviation.
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The model is applied separately using finite difference – CFD coupling and standalone FEM formulations.
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Interstitial oedema due to fourth ventricle outlet obstruction can be observed to be alleviated via simulated endoscopic fourth ventriculostomy.
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Periventricular lucency can be observed using the FEM based formulation.