Characteristics of IFN-¦Ã responses in IGRA among pulmonary TB suspects in a TB-endemic area

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• 作者：Jia-Yih Feng ; Shiang-Fen Huang ; Ming-Che Lee ; Wen-Ying Ting ; Yu-Chun Chen ; Yung-Yang Lin ; Yu-Chin Lee ; Wei-Juin Su
• 关键词：Active pulmonary tuberculosis ; IGRA ; IFN-¦Ã ; QFT-GIT ; TB suspects
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：77
• 期：1
• 页码：46-52
• 全文大小：674 K

文摘

Although the diagnostic value of interferon-¦Ã (IFN-¦Ã) release assays for active tuberculosis (TB) is limited, the characteristic of non-TB-specific IFN-¦Ã responses among TB suspects deserves further evaluation. We enrolled clinically suspected pulmonary TB (PTB) patients, and QuantiFERON-TB Gold In-Tube (QFT-GIT) was performed. The characteristics of IFN-¦Ã responses were analyzed. Among 392 patients, active PTB patients had stronger IFN-¦Ã responses to TB antigen (TBAg-Nil, P < 0.001) and lower responses to mitogen (Mitogen-Nil, P < 0.001). Lower body mass index (P = 0.001), without bacille Calmette-Guerin vaccination (P = 0.026), and active PTB (P = 0.011) were independent factors associated with lower non-TB-specific IFN-¦Ã responses. Among TB suspects with higher TBAg-Nil (>1.02 U/mL) and lower Mitogen-Nil (<5.5 U/mL), 84.3 % were active PTB cases. Among TB suspects with lower TBAg-Nil and higher Mitogen-Nil, only 4.7 % were active PTB. The present study suggested that the possibilities of active PTB should be carefully excluded in TB suspects with stronger TB-specific and lower non-TB-specific IFN-¦Ã responses in QFT-GIT.