Eicosapentaenoic acid-containing phosphatidylcholine alleviated lipid accumulation in orotic acid-induced non-alcoholic fatty liver
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- 作者：Yanjun Liua ; Di Shia ; Yuntao Liub ; Yanlei Zhaoa ; Yingying Tiana ; Jie Xua ; Jingfeng Wanga ; jfwang@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Changhu Xuea ; xuechanghuouc@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Adenosine monophosphate activated protein kinase ; Eicosapentaenoic acid-containing phosphatidylcholine ; Non-alcoholic fatty liver disease ; Peroxisome proliferators activated receptor α ; Sterol regulatory element binding protein-1c
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：23
- 期：Complete
- 页码：294-305
- 全文大小：2024 K
文摘
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The alleviating effect of EPA-PC on non-alcoholic fatty liver disease was tested.
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EPA-PC regulated key enzyme activities in fatty acid synthesis, transport and β-oxidation.
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The mechanism involved regulating transcriptions of AMPK and its target genes.
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Our study predicted EPA-PC as a novel agent for non-alcoholic fatty liver disease.