Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation
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- 作者：Helen Shinru Wei1 ; Hongyi Kang1 ; Izad-Yar Daniel Rasheed2 ; Sitong Zhou3 ; Nanhong Lou1 ; Anna Gershteyn1 ; Evan Daniel McConnell1 ; Yixuan Wang3 ; 4 ; Kristopher Emil Richardson5 ; Andre Francis Palmer5 ; Chris Xu6 ; Jiandi Wan3 ; jdween@rit.edu" class="auth_mail" title="E-mail the corresponding author ; Maiken Nedergaard1 ; 7 ; nedergaard@urmc.rochester.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：17 August 2016
- 年：2016
- 卷：91
- 期：4
- 页码：851-862
- 全文大小：2430 K
文摘
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Activity-dependent cortical hyperemia begins in capillaries
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Transient dips in tissue O2 tension drive capillary hyperemia
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Depletion of O2 increases isolated erythrocyte flow velocity ex vivo
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Erythrocytes are O2 sensors that regulate their own deformability and flow velocity