The developmental transcriptome sequencing of bovine skeletal muscle reveals a long noncoding RNA, lncMD, promotes muscle differentiation by sponging miR-125b
详细信息 查看全文
- 作者：Xiaomei Suna ; b ; Mingxun Lia ; b ; Yujia Suna ; Hanfang Caia ; Xianyong Lana ; Yongzhen Huanga ; Yueyu Baic ; Xinglei Qid ; Hong Chena ; chenhong1212@263.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Long noncoding RNA ; Competing endogenous RNA ; Ribo-Zero RNA-Seq ; Muscle differentiation ; Cattle
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：1863
- 期：11
- 页码：2835-2845
- 全文大小：1715 K
文摘
- •
We report here the first analysis of lncRNA landscape during muscle development.
- •
lncMD is a muscle-specific lncRNA which is tightly regulated during myogenesis.
- •
lncMD promotes muscle differentiation by acting as a ceRNA for miR-125b.
- •
IGF2 is an important target of miR-125b in bovine myogenesis.
- •
lncMD increases IGF2 expression in a miR-125b-dependent manner.