Ligation of porcine Fc gamma receptor I inhibits levels of antiviral cytokine in response to PRRSV infection in vitro

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• 作者：Qingyuan Yang¹ ; Yina Zhang¹ ; Jing Chen ; Yonghui Zhou ; Na Li ; Yunjie Qin ; Mingfan Yang ; Pingan Xia ; ^{xpa88@163.com} ; ^{yangqingyuan57@163.com} ; Baoan Cui
• 关键词：Fc¦Ã receptor ; Fc¦ÃRI ; PRRSV ; Cytokine ; Pig
• 刊名：Virus Research
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：173
• 期：2
• 页码：421-425
• 全文大小：899 K

文摘

PRRSV infection ADE facilitates the attachment and internalization of the virus onto macrophages through Fc receptor-mediated endocytosis. Fc¦ÃRI is the activating receptor with a tyrosine-based activating motif (ITAM) in its cytoplasmic tail, where up-regulates phagocytosis. However, porcine Fc¦ÃRI's role in the antiviral immune response to PRRSV infection has not been studied. In this study, our results indicated that selective activation of porcine Fc¦ÃRI in PAM cells down-regulated significantly mRNA levels of IFN-¦Á and TNF-¦Á post-pretreatment, suggesting that porcine Fc¦ÃRI signal can inhibit the innate antiviral response of host cells. PRRSV infection assay mediated by Fc¦ÃRI indicated that selective activation of porcine Fc¦ÃRI in PAM cells inhibited significantly mRNA levels of antiviral cytokine (IFN-¦Á and TNF-¦Á) in response to PRRSV infection, suggesting that Fc¦ÃRI ligation can inhibit the antiviral immune response to PRRSV infection.