Identification of known chemicals and their metabolites from Alpinia oxyphylla fruit extract in rat plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) with selected reaction monitoring
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- 作者：Feng Chena ; b ; cy.chen508@gmail.com" class="auth_mail ; Hai-Long Lia ; b ; Yin-Feng Tana ; b ; Yong-Hui Lia ; b ; Wei-Yong Laia ; b ; Wei-Wei Guana ; b ; Jun-Qing Zhanga ; b ; jqzhang2011@163.com" class="auth_mail ; Yuan-Sheng Zhaoc ; Zhen-Miao Qina ; b
- 关键词：Yizhi extract ; Flavonoids ; Diarylheptanoids ; LC&ndash ; MS/MS ; Target analysis
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：25 August 2014
- 年：2014
- 卷：97
- 期：Complete
- 页码：166-177
- 全文大小：3076 K
文摘
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Alpinia oxyphylla (Yizhi) capsularfruits are commonly used in traditional medicine.
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The chemicals and their metabolites in rat plasma were identified using LC–MS/MS with MRM mode.
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Yizhi flavonoids and diarylheptanoids formed mainly monoglucuronide metabolites.
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Metabolic reduction of Yizhi diarylheptanoids occurred in rats.
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