A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism
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- 作者：Yanlin He1 ; 6 ; Gang Shu1 ; 2 ; 6 ; Yongjie Yang1 ; Pingwen Xu1 ; Yan Xia1 ; Chunmei Wang1 ; Kenji Saito1 ; Antentor Hinton Jr.1 ; Xiaofeng Yan1 ; Chen Liu3 ; Qi Wu1 ; Qingchun Tong4 ; Yong Xu1 ; 5 ; 7 ; yongx@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：food intake ; energy expenditure ; body weight ; AgRP/NPY neurons ; SK3
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：17
- 期：7
- 页码：1807-1818
- 全文大小：3075 K
文摘
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Fasting dramatically diminishes SK3 expression in AgRP/NPY neurons
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Mutation of SK3 in AgRP/NPY neurons increases their activity in the fed state
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Mutation of SK3 in AgRP/NPY neurons facilitates diet-induced obesity
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Mutation of SK3 in AgRP/NPY neurons causes hyperphagia and hypometabolism