Biocompatible cationic pullulan-g-desoxycholic acid-g-PEI micelles used to co-deliver drug and gene for cancer therapy
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- 作者：Lili Chena ; b ; Fangling Jib ; Yongming Baob ; Jing Xiaa ; b ; Lianying Guoc ; Jingyun Wanga ; b ; wangjingyun67@dlut.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yachen Lic ; liy76@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pullulan ; Co-delivery ; Biocompatibility ; DOX ; p53 ; Cancer therapy
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：418-429
- 全文大小：1800 K
文摘
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A new amphiphilic bifunctional pullulan derivative (named as PDP) was prepared.
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PDP exhibited good blood compatibility and low cytotoxicity.
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PDP formed cationic core-shell nanomicelles, loading drugs and genes simultaneously.
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PDP/DOX/p53 micelles exhibited higher antitumor efficacy in vitro and in vivo.
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PDP holds great promise in combined drug/gene treatment for efficient cancer therapy.