EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance

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• 作者：Shuhang Wang^a ; Yongping Song^b ; Delong Liu^b ; ^{delong_liu@nymc.edu}
• 关键词：EGFR ; EAI045 ; TKI ; AZD9291 ; Rociletinib
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：51-54
• 全文大小：416 K
• 卷排序：385

文摘

Drug resistance develops rapidly with the tyrosine kinase inhibitor therapy for advanced non-small cell lung cancer. Acquired mutations have been found to mediate the resistance. New small molecule inhibitors targeting these new mutations are being developed. This minireview summarizes the latest development in searching for a novel agent as the fourth generation inhibitor for EGFR.