High-throughput transcriptome sequencing reveals the combined effects of key e-waste contaminants, decabromodiphenyl ether (BDE-209) and lead, in zebrafish larvae
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- 作者：Lianguo Chena ; b ; Biran Zhua ; Yongyong Guoa ; Tao Xuc ; Jae-Seong Leed ; Pei-Yuan Qianb ; Bingsheng Zhoua ; bszhou@ihb.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDE-209 ; Pb ; Zebrafish embryos ; Developmental co-exposure ; Transcriptome
- 刊名：Environmental Pollution
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：214
- 期：Complete
- 页码：324-333
- 全文大小：1807 K
文摘
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Zebrafish larvae were co-exposed to BDE-209 and Pb, major e-waste contaminants.
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Their transcriptional profiles and phenotypic endpoints were examined 6 dpf.
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The steroidogenic pathway and vitellogenesis were stimulated by BDE-209.
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Pb exposure caused cardiac dysfunction and affected neuroendocrine regulation.
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Co-exposure led to synergistic and antagonistic effects on gene transcriptions.