Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population

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• 作者：Qian Zhao ; Ronglin Che ; Zhao Zhang ; Peng Wang ; Jun Li ; You Li ; Ke Huang ; Wei Tang ; Guoyin Feng ; Klaus Lindpaintner ; Lin He ; Yongyong Shi
• 关键词：Genetic association ; Bipolar disorder ; GRIN2B
• 刊名：Psychiatry Research
• 出版年：2011
• 出版时间：30 January 2011
• 年：2011
• 卷：185
• 期：1-2
• 页码：290-292
• 全文大小：132 K

文摘

In the present work we genotyped three single-nucleotide polymorphisms (SNPs) (rs7301328, rs1805247, and rs1805502) of the GRIN2B gene in a set of 480 unrelated bipolar disorder patients and 480 unrelated genetically matched normal controls in Chinese Han population by either allelic-specific multiplex ligation-detection reaction (AMLR) technology or direct sequencing. Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder.