Vitamin D Deficiency as a Potential Marker of Benign Prostatic Hyperplasia

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• 作者：Weibing Zhang ; Xinmin Zheng ; ^{zhangweibin1969@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yongzhi Wang ; He Xiao
• 刊名：Urology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：97
• 期：Complete
• 页码：212-218
• 全文大小：211 K

文摘

To determine whether prostatic volumes and urinary flow changes were higher in old Chinese men with vitamin D deficiency than in those without vitamin D deficiency.

Methods

This was an observational case-control study of 224 old Chinese men. End point variables were prostatic volume, measured by transrectal ultrasound, and urinary flow, measured by urinary flowmetry. The International Prostate Symptom Score and International Index of Erectile Function score were determined.

Results

Two hundred and thirty-one (71.7%) out of the 322 were defined as vitamin D deficiency. The vitamin D deficiency group had a significantly higher prostate volume (42 mL vs 28 mL, P < .001), aldosterone (293 pg/mL vs 220 pg/mL, P < .001), prostate-specific antigen value (3.28 ng/mL vs 2.55 ng/mL, P < .001), and IPSS (4.47 vs 1.98, P < .001), and a significantly lower maximum urinary flow (13.44 mL/s vs 29.98 mL/s, P < .001) vs free of vitamin D deficiency group. Binary logistic regression analysis showed a strong association between the presence of vitamin D deficiency and benign prostatic hyperplasia (BPH) after adjusting for age, International Prostate Symptom Score, urination time, urinary volume, abdominal obesity, aldosterone, glucose, insulin, parathyroid hormone, and C-reactive protein (odds ratio 5.22, 95% confidence interval 1.96-12.76, P = .001).

Conclusion

There is a relationship between the presence of vitamin D deficiency and prostate growth-associated urinary symptoms, likely attributable to their pathophysiological similarity. This study suggests that vitamin D deficiency may be a marker of BPH. Thus, it may be used as a future therapeutic target in patients with BPH. Further studies were necessary to confirm this association.