p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

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• 作者：Ran Brosh ; Rachel Sarig ; Elad Bar Natan ; Alina Molchadsky ; Shalom Madar ; Chamutal Bornstein ; Yosef Buganim ; Tirosh Shapira ; Naomi Goldfinger ; Ralf Paus ; Varda Rotter
• 关键词：XEDAR ; Alopecia ; Cyclophosphamide ; Knockout ; Chemotherapy-induced alopecia
• 刊名：FEBS Letters
• 出版年：2010
• 出版时间：3 June 2010
• 年：2010
• 卷：584
• 期：11
• 页码：2473-2477
• 全文大小：409 K

文摘

The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.