Administration of tauroursodeoxycholic acid enhances osteogenic differentiation of bone marrow-derived mesenchymal stem cells and bone regeneration
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- 作者：Byung-Hyun Chaa ; 1 ; Moon-Joo Jungb ; 1 ; Bo-Kyung Moona ; Jin-Su Kima ; Yoonji Mab ; Yoshie Araia ; Myungkyung Nohb ; Jung-Youn Shinb ; Byung-Soo Kimb ; c ; d ; byungskim@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Soo-Hong Leea ; soohong@cha.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tauroursodeoxycholic acid ; Mesenchymal stem cells ; Apoptosis ; Inflammatory ; Osteogenic differentiation ; Bone tissue regeneration
- 刊名：Bone
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：73-81
- 全文大小：1095 K
文摘
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Tauroursodeoxycholic acid (TUDCA) promotes osteogenic differentiation of mouse bone marrow mesenchymal stem cells (mBMMSCs).
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TUDCA stimulates Integrin 5 (ITGA5) associated with activation of ERK1/2 signal pathway.
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TUDCA enhances bone tissue regeneration by the suppression of apoptosis and inflammatory response.
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TUDCA promotes bone tissue regeneration in mouse calvarial defects.
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Ursodeoxycholic acid (UDCA), which has a similar chemical structure to TUDCA, also increases bone regeneration.
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TUDCA is a useful pharmacological substitute for BMP-2, which is clinically available for bone tissue regeneration.