Microglia express a functional receptor for interleukin-23

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• 作者：Yoshifumi Sonobe ; Jiangfeng Liang ; Shijie Jin ; Guiqin Zhang ; Hideyuki Takeuchi ; Tetsuya Mizuno ; Akio Suzumura
• 关键词：Microglia ; IL-23 ; Chemokine
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2008
• 出版时间：23 May 2008
• 年：2008
• 卷：370
• 期：1
• 页码：129-133
• 全文大小：538 K

文摘

Interleukin (IL)-23 plays a predominant role in the development of autoimmune diseases by inducing IL-17-producing helper T (Th17) cells. The receptor for IL-23 consists of a heterodimer composed of the IL-12 receptor β1 (IL-12Rβ1) and the IL-23 receptor (IL-23R), which is mainly expressed on Th17 cells. A recent study showed that macrophages express IL-23R mRNA and can be distinguished from microglia by IL-23R expression. However, in this study, we show by RT-PCR and immunocytochemistry that microglia express IL-23R and IL-12Rβ1 mRNA and protein, respectively. Additionally, microglia expressed a functional receptor for IL-23, as IL-23 enhanced the Interferon (IFN)-γ-induced signal transducer and activator of transcription (STAT)1 phosphorylation and chemokine production. Thus, IL-23R expression does not discriminate peripheral macrophages from microglia. Moreover, since microglia produce IL-23, it may function in an autocrine manner to recruit inflammatory cells by inducing chemokine production.