Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes

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• 作者：Yi Cheng ; Hideyuki Takeuchi ; ^{htake@riem.nagoya-u.ac.jp" class="auth_mail} ; Yoshifumi Sonobe ; Shijie Jin ; Yue Wang ; Hiroshi Horiuchi ; Bijay Parajuli ; Jun Kawanokuchi ; Tetsuya Mizuno ; Akio Suzumura
• 关键词：Sirtuin 1 ; Astrocyte ; Superoxide dismutase 2 ; Catalase ; Forkhead box protein O4 ; Reactive oxygen species
• 刊名：Journal of Neuroimmunology
• 出版年：15 April, 2014
• 年：2014
• 卷：269
• 期：1-2
• 页码：38-43
• 全文大小：942 K

文摘

Sirtuin 1 (SIRT1) exerts a neuroprotective effect on various neurologic diseases. Here we investigated the protective functions of SIRT1 in astrocytes, which are the most abundant cells in the central nervous system. Upregulation of SIRT1 suppressed the expression levels of pro-inflammatory cytokines and increased the expression levels of superoxide dismutase 2 and catalase. Inversely, inhibition of SIRT1 significantly increased the acetylation of forkhead box protein O4, decreased the expression levels of superoxide dismutase 2 and catalase, and increased the production of reactive oxygen species. Our data suggest that astrocytic SIRT1 may elicit neuroprotective effects through its anti-oxidative and anti-inflammatory functions.