Preparation and evaluation of a novel wound dressing sheet comprised of β-glucan–chitosan complex

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• 作者：Kyoko Kofuji ; Yuzhou Huang ; Kazufumi Tsubaki ; Fumihiko Kokido ; Kazunori Nishikawa ; Takashi Isobe ; Yoshifumi Murata
• 关键词：β ; -Glucan ; Chitosan ; Complex ; Wound dressing ; Sheet
• 刊名：Reactive and Functional Polymers
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：70
• 期：10
• 页码：784-789
• 全文大小：641 K

文摘

A transparent wound dressing sheet was obtained by forming a complex between β-glucan and chitosan (CS). These materials were chosen for their biocompatible, bioabsorbable, and biodegradable properties, and they were expected to promote the therapeutic efficacy of the dressing by increasing the wound healing response. The therapeutic efficacy of the β-glucan–CS complex sheet as a wound dressing was evaluated in wounds created on the dorsal surfaces of mice. β-glucan–CS complex sheets demonstrated therapeutic efficacies comparable or superior to that of Beschitin®W, a commercial wound dressing made from CS. Additionally, the β-glucan–CS complex sheet did not dissolve during the application period, did not adhere to wounds, and was easy to remove. Cumulatively, these results indicate that β-glucan–CS complex sheets are a promising new wound dressing product.