Evaluation of postoperative antibiotic prophylaxis after liver resection: a randomized controlled trial

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• 作者：Fumitoshi Hirokawa ; M.D.^a ; ^{sur122@poh.osaka-med.ac.jp} ; Michihiro Hayashi ; M.D.^a ; Yoshiharu Miyamoto ; M.D.^a ; Mitsuhiro Asakuma ; M.D.^a ; Tetsunosuke Shimizu ; M.D.^a ; Koji Komeda ; M.D.^a ; Yoshihiro Inoue ; M.D.^a ; Kazuhisa Uchiyama ; M.D.^a ; Yasuichiro Nishimura ; Ph.D.^b
• 关键词：Liver resection ; Postoperative antibiotic therapy ; Postoperative infections
• 刊名：The American Journal of Surgery
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：206
• 期：1
• 页码：8-15
• 全文大小：324 K

文摘

Background

Antibiotic prophylaxis is frequently administered after liver resection to prevent postoperative infections. However, very few studies have examined the usefulness of antibiotic prophylaxis after liver resection. A randomized controlled trial was conducted to evaluate the postoperative antibiotic prophylaxis in patients after liver resection.

Methods

A total of 241 patients scheduled to undergo liver resection were randomly assigned to the non-postoperative antibiotic group (n = 95) or the antibiotic group (n = 95). The antibiotic group was given flomoxef sodium every 12 hours for 3 days after the operation. The end point was signs of infection, surgical site infection, or infectious complications.

Results

There were no significant differences between the 2 groups in signs of infection (21.3 % vs 25.5 % , P = .606), the incidence of systemic inflammatory response syndrome (11.7 % vs 17.0 % , P?= .406), infectious complications (7.5 % vs 17.0 % , P = .073), surgical site infection (10.6 % vs 13.8 % , P = .657), and remote site infection (2.1 % vs 8.5 % , P = .100).

Conclusions

Postoperative antibiotic prophylaxis cannot prevent postoperative infections after liver resection, and it is thought that antibiotic prophylaxis is unnecessary and costly.