Are clinicopathological features of colorectal cancers with methylation in half of CpG island methylator phenotype panel markers different from those of CpG island methylator phenotype-high colorectal cancers?

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• 作者：Jeong Mo Bae ; MD^a ; ¹ ; ^{jeongmobae@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ye-Young Rhee ; MD^a ; ¹ ; ^{songyyii@naver.com" class="auth_mail" title="E-mail the corresponding author} ; Kyung Ju Kim ; MD^a ; ^{sonicker@naver.com" class="auth_mail" title="E-mail the corresponding author} ; Xianyu Wen ; MSc^a ; ^b ; ^{hyunwoo625@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Young Seok Song ; MSc^b ; ^{suky0215@naver.com" class="auth_mail" title="E-mail the corresponding author} ; Nam-Yun Cho ; MSc^b ; ^{chonamyun@hanmail.net" class="auth_mail" title="E-mail the corresponding author} ; Jung Ho Kim ; MD ; PhD^a ; Gyeong Hoon Kang ; MD ; PhD^a ; ^b ; ^{ghkang@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Colorectal cancer ; CpG island methylator phenotype ; DNA methylation ; Marker ; Prognosis
• 刊名：Human Pathology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：47
• 期：1
• 页码：85-94
• 全文大小：1415 K

文摘

CpG island methylator phenotype (CIMP)–high (CIMP-H) colorectal cancer (CRC) is defined when a tumor shows methylation at greater than or equal to 60% of CIMP panel markers. Although CRCs with methylation at 50% of panel markers are classified as CIMP-low/CIMP-0 tumors, little is known regarding the clinicopathological and molecular features of CRCs with methylation at 4/8 panel markers (4/8 methylated markers) and whether they are akin to CIMP-H or CIMP-low/CIMP-0 CRCs in terms of their clinicopathological or molecular features. A total of 1164 cases of surgically resected CRC were analyzed for their methylation status in 8 CIMP panel markers, and the frequencies of various clinicopathological and molecular features were compared between CRCs with 0/8, 1/8 to 3/8, 4/8, and 5/8 to 8/8 methylated markers. CRCs with 4/8 methylated markers were closer to CRCs with 5/8 to 8/8 methylated markers in terms of sex distribution, mucin production, serration, nodal metastasis, CK7 expression, CK20 loss, and CDX2 loss frequencies and overall survival rate. CRCs with methylation at 4/8 markers were closer to CRCs with 1/8 to 3/8 methylated markers in terms of less frequent right colon location and poor differentiation. CRCs with 4/8 methylated markers showed the shortest overall survival time compared with CRCs with 0/8, 1/8 to 3/8, 4/8, or 5/8 to 8/8 methylated markers. In terms of clinicopathological and molecular features, CRCs with 4/8 methylated markers appeared to be closer to CIMP-H than to CIMP-low/CIMP-0 and would thus be better classified as CIMP-H if the CRCs require classification into either CIMP-H or CIMP-low/CIMP-0.