CD4⁺FoxP3⁺ T regulatory cells in drug-susceptible and multidrug-resistant tuberculosis

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• 作者：Hyo-Jeong Lim ; Jong Sun Park ; Young-Jae Cho ; Ho Il Yoon ; Kyoung Un Park ; Choon-Tack Lee ; Jae Ho Lee
• 关键词：Disease susceptibility ; Regulatory T-cells ; FoxP3 protein ; Multidrug-resistant tuberculosis
• 刊名：Tuberculosis
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：93
• 期：5
• 页码：523-528
• 全文大小：700 K

文摘

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Summary

Regulatory T cells (T_reg) increase in active tuberculosis (TB). However, whether T_reg-mediated immune suppression affect the susceptibility to active TB or development of multidrug-resistant (MDR) TB is not yet clear. We compared circulatory T_reg frequencies in drug susceptible (DS) and MDR TB before and after anti-TB treatment.

Circulatory T_reg frequencies were measured in blood samples from 33 DS TB, 7 mycobacterial culture-positive active MDR TB, 16 stable MDR TB who had been culture negative for at least 6 months, and 14 healthy controls before and after treatment. T_reg frequency was measured by flow cytometry using cell-surface marker CD4 and intracellular marker FoxP3.

T_reg frequency was higher in DS TB and active MDR TB patients than in healthy controls (p?<?0.05), with no significant difference between the former. T_reg frequency was higher in patients with sputum acid-fast bacilli smear-positive TB than in patients with smear-negative TB, but the increase did not correlate with the radiologic extent of TB or presence of a cavity. After successful treatment, T_reg decreased to control levels in DS TB and MDR TB patents.

The pattern of change, in which T_reg frequency increased during active infection and normalized to control levels after successful treatment, was similar in DS and MDR TB patients.