Progesterone supplementation for prevention of preterm labor: A randomized controlled trial

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• 作者：Moustafa Ibrahim ; ^{mi_monem@yahoo.com} ; Ahmed Ramy Mohamed Ramy ; Moustafa Abdel-Fattah Younis
• 关键词：Preterm labor ; Progesterone ; Prevention of preterm labor
• 刊名：Middle East Fertility Society Journal
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：15
• 期：1
• 页码：39-41
• 全文大小：288 K

文摘

Objective

To evaluate the efficacy of intramuscular progesterone in prevention of preterm labor in high risk cases.

Design

Randomized controlled trial.

Setting

Ain Shams Maternity hospital.

Materials and methods

Singleton pregnant women in their second trimester with a history of previous preterm labor were divided into two groups: progesterone group: received 17-¦Á-hydroxy progesterone caproate (Cidolut depot) one dose of 250 mg IM once weekly until 36 weeks and placebo group: received standard dose of placebo IM per week. Follow up till delivery.

Results

The mean gestational age was 37.4 ¡À 1.5 in progesterone group vs. 34.7 ¡À 2.4 in placebo group (P < 0.05). In the progesterone group 8 of 25 women delivered before completion of 37 weeks of gestation (32 % ) and 17 women delivered full term (68 % ). In placebo group, 13 of 25 women delivered before completion of 37 weeks of gestation (52 % ) and 12 women delivered full term (48 % ).

Conclusion

Our findings support 17-¦Á-hydroxy progesterone as a successful drug in the prevention and decreasing the rate of recurrent preterm labor.