The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice

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• 作者：San-Ming Deng^a ; ^f ; ¹ ; Xian-Chun Yan^a ; ¹ ; Liang Liang^a ; ¹ ; Li Wang^a ; ¹ ; Yuan Liu^a ; Juan-Li Duan^c ; Zi-Yan Yang^a ; Tian-Fang Chang^d ; Bai Ruan^c ; Qi-Jun Zheng^e ; ^{zhengqj@fmmu.edu.cn} ; Hua Han^a ; ^b ; ^{huahan@fmmu.edu.cn}
• 关键词：Lung cancer ; Notch ; Delta-like 3 ; Hypoxia ; TNF-α
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：488-494
• 全文大小：1732 K
• 卷排序：483

文摘

The level of Dll3 in Lewis lung carcinoma changed upon tumor microenvironment (TME) stimulation, namely, decreased under hypoxia or stimulated with TNF-α. The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of NSCLC tissues from 84 patients. Overexpression of Dll3 in LLC cells promoted tumor growth but did not remarkably alter TME after inoculated in mice. Overexpression of Dll3 in LLC cells promoted cell proliferation and reduced apoptosis in vitro in an Akt-dependent way. Dll3 overexpression promoted PI3K/Akt signaling through inhibiting Notch signaling.