Expression of mesothelin in thymic carcinoma and its potential therapeutic significance
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- 作者：Anish Thomas ; MDa ; Yuanbin Chen ; MD PhDa ; Arlene Berman ; MSa ; David S. Schrump ; MDa ; Giuseppe Giaccone ; MD PhDb ; Ira Pastan ; MDc ; David J. Venzon ; PhDd ; David J. Liewehr ; MSd ; Seth M. Steinberg ; PhDd ; Markku Miettinen ; MDe ; Raffit Hassan ; MDa ; Arun Rajan ; MDa ; rajana@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Thymic carcinoma ; Mesothelin ; Immunohistochemistry ; Therapeutic target ; Immunotherapy
- 刊名：Lung Cancer
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：104-110
- 全文大小：1846 K
文摘
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Mesothelin, a cell surface antigen is a target for tumor-directed therapy.
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Thymic carcinomas frequently demonstrate strong mesothelin expression.
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High mesothelin expression in thymic carcinoma is associated with longer survival.
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Mesothelin-directed therapy should be evaluated in advanced thymic carcinoma.