螖hupA mutant was found to be defective in cell growth, H2S production, and acid adaptation in log phase cultures.
螖hupA mutant up-regulated the transcription levels of recA and sulA, resulting in filamentous morphology.
螖hupA mutant showed a striking defect in EPC cell invasion, and the adhesion and internalization rates were reduced to 25% and 27% of the wild-type in log phase cultures.
螖hupA mutant reduced proliferation abilities in the muscle, liver and intestine of zebrafish.