Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia
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- 作者：Hao Huanga ; Xi Jianga ; b ; Jinhua Wanga ; Yuanyuan Lia ; Chun-Xiao Songc ; Ping Chena ; Shenglai Lia ; Sandeep Gurbuxanid ; Stephen Arnovitza ; Yungui Wanga ; b ; Hengyou Wenga ; b ; Mary Beth Neillya ; Chuan Hec ; Zejuan Lia ; Jianjun Chena ; b ; Chen3jj@uc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MLL-rearranged leukemia ; miR-26a ; TET1 ; MYC ; Post-transcription regulation
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 March 2016
- 年：2016
- 卷：372
- 期：2
- 页码：157-165
- 全文大小：2022 K
文摘
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miR-26a is significantly down-regulated in MLL-rearranged AML.
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miR-26a plays a critical anti-leukemic function both in vitro and in vivo.
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TET1 is a direct target gene of miR-26a in MLL-rearranged AML.
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TET1's overexpression and oncogenic role in MLL AML rely on suppression of miR-26a.
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MYC mediates the transcriptional suppression of miR-26a in MLL-rearranged AML.
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