Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells
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- 作者：Yingying Pu1 ; 5 ; Zhilun Zhao1 ; 5 ; Yingxing Li1 ; 5 ; Jin Zou1 ; Qi Ma1 ; Yanna Zhao1 ; Yuehua Ke1 ; Yun Zhu1 ; Huiyi Chen2 ; Matthew A.B. Baker3 ; Hao Ge1 ; 4 ; Yujie Sun1 ; Xiaoliang Sunney Xie1 ; 2 ; xie@chemistry.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Fan Bai1 ; fbai@pku.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：62
- 期：2
- 页码：284-294
- 全文大小：3348 K
文摘
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Persisters accumulate fewer antibiotics as a direct result of increased efflux rate
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Persisters show higher expression of efflux-associated genes
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High expression of tolC is critical to promote persister formation
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Persisters combine active efflux and passive dormancy to survive antibiotic attack