An in vivo assay performed using multiple biomarkers related to testosterone synthesis and conversion for assessing the androgenic potency of refuse leachate
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- 作者：Yufeng Gong ; Hua Tian ; Yifei Dong ; Xiaona Zhang ; Wei Wang ; weiwang@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shaoguo Ru ; rusg@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AR ; androgen receptor ; T ; testosterone ; TBT ; tributyltin ; P450arom ; P450 aromatase ; GtHs ; gonadotropins ; LH ; luteinizing hormone ; FSH ; follicle-stimulating hormone ; E2 ; 17β-estradiol ; Vtg ; vitellogenin ; GSI ; gonadosomatic index ; γ-GTP ; gamma-glutamyl transpeptidase ; ACP ; acid phosphatase ; ALP ; alkaline phosphatase ; MBR ; membrane bioreactor ; DTRO ; disc-tube reverse osmosis ; RIA ; radioimmunoassay ; PCR ; polymerase chain reaction
- 刊名：Ecotoxicology and Environmental Safety
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：135
- 期：Complete
- 页码：82-89
- 全文大小：1923 K
文摘
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Information on potential androgenic activity of refuse leachate is limited.
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An in vivo assay was developed using multiple biomarkers.
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Plasma T and LH levels increased, but 17β-estradiol levels decreased in goldfish.
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Treatment with leachate also induced reproductive impairments.
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This assay allowed assessing the potential androgenic activity of refuse leachate.