Equine schlafen 11 restricts the production of equine infectious anemia virus via a codon usage-dependent mechanism
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- 作者：Yue-Zhi Lina ; 1 ; sndhr@163.com" class="auth_mail" title="E-mail the corresponding author ; Liu-Ke Suna ; 1 ; sunlk0916@126.com" class="auth_mail" title="E-mail the corresponding author ; Dan-Tong Zhua ; b ; zhudantong123@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhe Hua ; huzher@126.com" class="auth_mail" title="E-mail the corresponding author ; Xue-Feng Wanga ; xuefengwang1982@126.com" class="auth_mail" title="E-mail the corresponding author ; Cheng Dua ; chengdu1981@163.com" class="auth_mail" title="E-mail the corresponding author ; Yu-Hong Wangc ; wang_yu_hong@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiao-Jun Wanga ; xjw@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Jian-Hua Zhoua ; jianhua_uc@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SLFN11 ; Equine infectious anemia virus ; Relative synonymous codon usage
- 刊名：Virology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：495
- 期：Complete
- 页码：112-121
- 全文大小：2114 K
文摘
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The expression of equine SLFN11 is upregulated by EIAV infection and INF-α.
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eSLFN11 suppresses EIAV late protein, but not early protein and vRNA syntheses.
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The eSLFN11 restriction activity is based on the codon usage preference between virus and host.