Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment
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- 作者：Lubing Gu1 ; 4 ; Hailong Zhang1 ; 4 ; Tao Liu1 ; 4 ; Sheng Zhou3 ; 4 ; Yuhong Du2 ; Jing Xiong3 ; Sha Yi1 ; Cheng-Kui Qu1 ; Haian Fu2 ; Muxiang Zhou1 ; 5 ; mzhou@emory.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：30
- 期：4
- 页码：623-636
- 全文大小：5198 K
文摘
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MDM2/XIAP inhibitors are selected by FP-HTS via blocking MDM2-XIAP IRES interaction
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MDM2/XIAP inhibitors degrade MDM2, activate p53, and inhibit XIAP expression
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MDM2/XIAP inhibitors exhibit anticancer activity in vitro and in animal models
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One of the MDM2/XIAP inhibitors MX69 is very well tolerated in animals