IL-13 polymorphisms contribute to the risk of asthma: A meta-analysis

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• 作者：Lin Cui^a ; ¹ ; Jing Jia^b ; ¹ ; Chun-Fen Ma^c ; ^{chunfenma@163.com} ; Su-Yun Li^a ; You-Ping Wang^a ; Xiao-Min Guo^d ; Qiang Li^a ; Hai-Bin Yu^a ; Wei-Hong Liu^a ; Lin-Bo Gao^e ; ^f ; ^{cdchglb@gmail.com}
• 关键词：Asthma ; IL-13 ; Meta-analysis ; Polymorphism
• 刊名：Clinical Biochemistry
• 出版年：2012
• 出版时间：March, 2012
• 年：2012
• 卷：45
• 期：4-5
• 页码：285-288
• 全文大小：341 K

文摘

Objectives

The purpose of this study was to evaluate the effects of interleukin-13 (IL-13) polymorphisms on the risk of asthma using a meta-analysis.

Design and methods

Fifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO databases. Odds ratios with corresponding 95 % confidence intervals were computed to estimate the association between IL-13 polymorphisms and risk of asthma.

Results

The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses. Subgroup analyses showed that the elevated risks occurred in adult-onset asthma, Caucasians, and high quality studies.

Conclusions

This meta-analysis provides evidence that the R130Q and -1112C/T polymorphisms in IL-13 are risk factors for asthma.