A rapid and comprehensive quality assessing method of Yin-Qiao-Jie-Du tablets using UHPLC-QTOF-MS in combination with multivariate statistical analysis
详细信息 查看全文
- 作者：Liping Hea ; 1 ; Yong Chenb ; 1 ; Ziqiao Liangb ; d ; Youzhi Lib ; d ; Minglin Zhoua ; Zhiquan Yuane ; Ling Luoc ; Zhen Jinc ; Yunyun Yangb ; yy_yang@vip.126.com" class="auth_mail" title="E-mail the corresponding author ; Jianxin Chenc ; jxchen@scau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ultra-high performance liquid chromatography ; Quadrupole time-of-flight mass spectrometry ; Yin-Qiao-Jie-Du tablet ; Active ingredients ; Orthogonal partial-least squares to latent structures discriminant analysis
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：30 May 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：129-137
- 全文大小：1221 K
文摘
- •
A method of UHPLC-QTOF-MS was developed for analysis of Yin-Qiao-Jie-Du tablets.
- •
A good separation was achieved within 30 min and 41 major peaks were obtained.
- •
31 of constituents were identified according to obtained MS data and retention time.
- •
Contents of 21 ingredients from18 batches of YQJD tablets were applied for OPLS-DA.
- •
OPLS-DA was successfully used for assessing the quality consistency and stability.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |