Goose haemorrhagic hepatitis caused by a new subtype duck hepatitis type 1 virus

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• 作者：Ming  ; Liu¹ ;   ; Fanyi-Meng¹ ; Xiao-jun  ; Li ; Zhuo  ; Zhang ; Siguo  ; Liu ; Yun  ; Zhang  ; ;   ; ^{yunzhang03@yahoo.com}
• 关键词：Duck hepatitis type 1 virus ; DHV-1 ; New geno- and serotype duck hepatitis type I virus ; DHV-1C ; Virus isolation ; Goose haemorrhagic hepatitis ; Characterization
• 刊名：Veterinary Microbiology
• 出版年：2011
• 出版时间：28 September 2011
• 年：2011
• 卷：152
• 期：3-4
• 页码：280-283
• 全文大小：497 K

文摘

Duck hepatitis type 1 virus (DHV-1) causes a fatal disease in ducklings but there is no report of DHV-1 isolation from goose. Recently, cases of a new disease in overfeeding geese were reported from China. The cases were characterized by haemorrhagic hepatitis lesions on liver after post mortem examinations. The flocks showed about 20?0 % morbidity and less than 5 % mortality. The histopathological lesions showed destroyed structure of hepatocytic tissue, severe vacuolation and necrosis of hepatocytes. Viral antigen could be detected by monoclonal antibody against duck hepatitis type 1 virus (DHV-1) in the cytoplasm of positive hepatocytes. PCR amplified viral sequences with primers specific for recent Korean-like duck hepatitis type 1 virus (DHV-1C). Alignment of the complete sequence demonstrated that the isolated JT strain from goose exhibiting 95.9 % identity to DHV-1C AP-03337 strain, and only 75.3 % to classical DHV-1 virus. 80 % goslings developed haemorrhagic hepatitis after infection with JT strain. This is the first report on the involvement of a DHV-1 virus in goose.