CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells
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- 作者：Yanjuan Houa ; b ; c ; 1 ; Ming Wuc ; 1 ; Jinying Weia ; c ; Yunzhuo Rena ; c ; Chunyang Dua ; c ; Haijiang Wua ; c ; Ying Lia ; b ; hebeiliying@126.com" class="auth_mail" title="E-mail the corresponding author ; Yonghong Shia ; c ; yonghongshi@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：High glucose ; CD36 ; Oxidative stress ; Renal tubular epithelial cell ; Epithelial to mesenchymal transition
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：281-286
- 全文大小：1379 K
文摘
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HG induced CD36 expression is dependent on ROS.
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Inhibition of CD36 attenuates HG-induced EMT and ROS generation.
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Inhibition of CD36 reduces HG-induced activation of ERK1/2 and Smad2.
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Inhibition of CD36 alleviates HG-induced TGF-β1 and fibronectin expression.
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