In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China

详细信息    查看全文

• 作者：Qiwen Yang^a ; ¹ ; Yingchun Xu^a ; ¹ ; Minjun Chen^a ; ^{chmj1933@hotmail.com} ; Hui Wang^b ; Hongli Sun^a ; Yunjian Hu^c ; Rong Zhang^d ; Qiong Duan^e ; Chao Zhuo^f ; Bin Cao^g ; Yong Liu^h ; Yunsong Yuⁱ ; Ziyong Sun^j ; Yunzhuo Chu^k
• 关键词：Cefditoren ; Streptococcus pneumoniae ; Haemophilus influenzae ; Moraxella catarrhalis ; Antimicrobial resistance
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：73
• 期：2
• 页码：187-191
• 全文大小：179 K

文摘

The aim of this study was to evaluate the in vitro activity of cefditoren and comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections (CARTIs). A total of 391 Streptococcus pneumoniae, 266 H. influenzae, and 76 M. catarrhalis were isolated from 10 centers located at 6 cities in China from January 2009 to May 2010. The microdilution method was used to determine minimum inhibitory concentrations (MICs). The pneumococci comprised 189 (48.3 % ) penicillin susceptible, 129 (33.0 % ) penicillin intermediate, and 73 (18.7 % ) penicillin resistant. Moxifloxacin and levofloxacin showed the highest activity (99.2 % and 97.7 % , respectively) against Streptococcus pneumoniae, followed by parenteral penicillin G (95.7 % ), cefditoren (83.1 % ) and amoxicillin-clavulanic acid (79.3 % ). Among the 266 H. influenzae isolates, 26 (9.8 % ) were ampicillin-resistant ¦Â-lactamase-producing strains and 24 (9.0 % ) were ampicillin-resistant ¦Â-lactamase-nonproducing strains (BLNAR). Most of antimicrobial agents demonstrated good activity (>97 % susceptibility) against H. influenzae except ampicillin, cefuroxime, and cefaclor, which showed relatively lower activity (81.2 % , 88.7 % , and 88 % , respectively). Cefditoren showed excellent activity with the lowest MIC₅₀ and MIC₉₀ (?.016/0.064 ¦Ìg/mL) among all tested drugs, which is independent of ¦Â-lactamase production or ampicillin resistance. Cefditoren at a concentration of 0.5 ¦Ìg/mL inhibited all BLNAR strains. Seventy of 76 isolates of M. catarrhalis produced ¦Â-lactamase. Cefditoren also showed excellent activity with MIC₉₀ of 0.064 ¦Ìg/mL against ¦Â-lactamase-nonproducing strains and 0.5 ¦Ìg/mL against ¦Â-lactamase-producing strains. In conclusion, the excellent intrinsic activity of cefditoren suggests that it may be a good choice for the treatment of CARTIs caused by Streptococcus pneumoniae, H. influenzae, and M. catarrhalis in China, while the activity should be closely monitored.