Effects of Ca²⁺ ions on bestrophin-1 surface films

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• 作者：Kirilka Mladenova^a ; Svetla D. Petrova^a ; Tonya D. Andreeva^b ; Veselina Moskova-Doumanova^c ; Tanya Topouzova-Hristova^c ; Yuri Kalvachev^d ; Konstantin Balashev^e ; Shomi S. Bhattacharya^f ; Christina Chakarova^g ; Zdravko Lalchev^a ; Jordan A. Doumanov^a ; ^{doumanov@biofac.uni-sofia.bg}
• 关键词：hBest1 ; Langmuir-Blodgett films ; AFM ; BAM ; FTIR ; π/A isotherms
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：226-232
• 全文大小：1247 K
• 卷排序：149

文摘

hBest1 secondary structure consists of 310-helices, α-helixes, β-turns and loops. Ca2+ ions induce conformational changes in the hBest1 secondary structure. Ca2+ ions cause changes in π/A isotherms and hysteresis of hBest1 monolayers. Ca2+ ions cause oligomerization, molecular and macro-organization in hBest1 films. Ca2+-induced functional switch could be related to protein macro-organization.